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Hematology - Diseases & USMLE MCQs
8 clinical summaries in hematology - each with pathophysiology, presentation, diagnosis, management, high-yield pearls, sample USMLE MCQs and an illustration from our medical library. Free to read, no login.
Acute Myeloid Leukemia (AML)
Clonal expansion of immature myeloid blasts causing marrow failure. Median age 68 y; presents with anaemia, thrombocytopenia and neutropenic infection.
Reviewed 12 Jul 2026
Chronic Lymphocytic Leukemia
Monoclonal proliferation of mature CD5+CD23+ B lymphocytes; most common adult leukaemia in the West with variable indolent to progressive course.
Reviewed 12 Jul 2026
Hemophilia A
X-linked recessive deficiency of coagulation factor VIII causing spontaneous and traumatic bleeding, especially haemarthrosis; severity by baseline factor level.
Reviewed 20 Jun 2026
Immune Thrombocytopenia (ITP)
Acquired autoimmune thrombocytopenia from anti-platelet antibodies causing isolated low platelets and mucocutaneous bleeding; diagnosis of exclusion.
Reviewed 30 May 2026
Iron Deficiency Anemia
Most common anaemia worldwide; results from blood loss, malabsorption or increased demand causing microcytic hypochromic red cells and low ferritin.
Reviewed 21 May 2026
Multiple Myeloma
Malignant plasma cell disorder producing monoclonal immunoglobulin (M-protein) with CRAB features: HyperCalcaemia, Renal impairment, Anaemia, Bone lesions.
Reviewed 8 May 2026
Sickle Cell Disease
Autosomal recessive haemoglobinopathy from HbS (beta-globin Glu6Val) that polymerises on deoxygenation, causing vaso-occlusion, haemolysis and end-organ damage.
Reviewed 30 Jun 2026
Thalassemia
Inherited disorder of globin chain synthesis causing microcytic anaemia; alpha (chromosome 16) or beta (chromosome 11) subtypes with wide severity range.
Reviewed 31 May 2026
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